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KMID : 0361519930040020138
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Korean Journal of Psychopharmacology
1993 Volume.4 No. 2 p.138 ~ p.145
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Influences of Difluoromethylornithine and Aminoguanidine on the ECS-induced Changes of the Brain Contents of Acetylcholine and Polyamines
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Abstract
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Zawia and Bondy (1990) propcsed the biological role of polyamines in the long-term adaptationsal response of the brain to eletrical stimulation. and Chol et al. (1990) suggested thast the interaction between polyamines and acetylcholine (Ach)
contents
of brains may be implicated with the delayed effects of repeated electroconvulsive shock (ECS).
In this study, the effects of ECS on the brain Ach and polyamine content of male ICR mice pretreated with DFMO and aminoguanidine were studied. DFMO (250mg/kg 8 times with 6hr interval : DFMO-8) and aminoguanidine (100mg/kg 4 times with 14hr
interval :
AG-4) were intraperitoneally injected. and mice were given a single ECS (13 mA. 100 cps. 1 sec) through bilateral ear-clip electrodes. DFMO-8 produced the significant decreases of the putrescine (PT) contents of temporal cortex (TCx) and
decorticated
cerebrum (dcCx). and AG-4 markedly increased the contents of both areas. But the brain contents of spermidine (SPD) and spermine(SM) were little affected by DFMO-8 or AG-4. The brain Ach content was moderately decreased by DFMO-8 but increased by
AG-8.
However. the ECS-induced changes of the brain Ach and polyamine contents and the ED50 of electroconvulsive current were iittle affected.
These results suggested that the brain polyamines may play a modulatory role in the basal metabolism and physiological reaction of the brain ACh system.
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KEYWORD
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